Negative regulation of actin filament depolymerization

Across TCGA cell cohorts, RNA activity of the Negative regulation of actin filament depolymerization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AGR2, CLDN4, and ZNF133, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AGR2 grouped by Negative regulation of actin filament depolymerization-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	AGR2 →	+6.181	+0.288	.002	.005	3	4
LUNG_NSCLC_LUSC	CLDN4 →	+3.110	+0.255	.004	.002	3	3
BREAST	ZNF133 →	-0.767	-0.214	<.001	.005	3	3
BREAST	GNG4 →	-1.635	-0.210	.005	.005	3	3
BREAST	KIZ →	-0.791	-0.359	<.001	.008	3	3
STOMACH	CFD →	+2.534	+0.341	.005	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AGR2 by Negative regulation of actin filament depolymerization activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →