Positive regulation of nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are IQGAP2_S16, TEP1, and C1orf35, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide biosynthetic process activity versus IQGAP2_S16 in LSCC (Pearson r = 0.36).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	IQGAP2_S16 →	+0.710	+0.077	<.001	<.001	3	5
LSCC	TEP1 →	+0.230	+0.053	<.001	<.001	3	5
LSCC	C1orf35 →	-0.321	-0.050	<.001	<.001	3	5
LSCC	AKT1S1_T246 →	+0.835	+0.048	<.001	.001	3	5
LSCC	LRWD1 →	-0.222	-0.039	.001	.006	3	5
COAD	SART3 →	-0.172	-0.034	.002	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030810 vs IQGAP2_S16 — LSCC

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