Positive regulation of nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Positive regulation of nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02669, MMP8, and ULK3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide biosynthetic process activity versus LINC02669 in BRCA (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC02669 →	+0.182	+0.418	.007	.003	3	3
LSCC	MMP8 →	+0.455	+0.608	<.001	<.001	3	3
HNSC	ULK3 →	-0.482	-0.557	.006	.001	3	3
HNSC	PPIAP2 →	-0.735	-0.726	<.001	.003	3	3
HNSC	P2RY11 →	-0.374	-0.583	.008	.005	2	4
HNSC	NCOA1 →	-0.502	-0.587	.007	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030810 vs LINC02669 — BRCA

Explore this scatter interactively →