Positive regulation of nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Positive regulation of nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMSB4X, POLR3GL, and L3MBTL3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of nucleotide biosynthetic process activity versus TMSB4X in LUNG_SCLC (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TMSB4X →	+1.893	+0.229	<.001	<.001	3	10
LARGE_INTESTINE	POLR3GL →	+0.615	+0.190	.001	.003	3	6
CNS	L3MBTL3 →	+0.699	+0.149	.006	.004	3	5
LARGE_INTESTINE	LAMP3 →	-1.751	-0.298	.002	.002	3	5
OESOPHAGUS	CDRT1 →	-1.593	-0.162	.002	.005	3	4
URINARY_TRACT	IFT81 →	+0.908	+0.440	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030810 vs TMSB4X — LUNG_SCLC

Explore this scatter interactively →