Negative regulation of nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of nucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ZEB1, LAMB2, and RBSN, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleotide biosynthetic process activity versus ZEB1 in CCRCC (Pearson r = -0.10).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZEB1 →	+0.403	+0.175	<.001	<.001	3	7
BRCA	LAMB2 →	+0.546	+0.047	<.001	<.001	3	7
BRCA	RBSN →	+0.249	+0.057	<.001	.001	3	7
OV	GSTA4 →	+0.642	+0.065	.003	.003	3	6
UCEC	VCAN →	+0.687	+0.100	.006	.001	3	6
CCRCC	LIX1L →	+0.338	+0.118	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030809 vs ZEB1 — CCRCC

Explore this scatter interactively →