Negative regulation of nucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Negative regulation of nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5P2, PSD4, and TNFAIP2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of nucleotide biosynthetic process activity versus FABP5P2 in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FABP5P2 →	+0.474	+0.534	.002	.002	3	4
GBM	PSD4 →	-0.586	-0.632	.002	<.001	3	3
PDAC	TNFAIP2 →	-0.370	-0.521	.002	.001	3	3
GBM	PDC →	+0.532	+0.466	.001	.003	3	3
GBM	PLEKHA8 →	+0.449	+0.473	<.001	.004	3	3
GBM	ANKRD26 →	+0.407	+0.513	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030809 vs FABP5P2 — GBM

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