Negative regulation of nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Negative regulation of nucleotide biosynthetic process pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLAAT3, GZF1, and GET1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLAAT3 grouped by Negative regulation of nucleotide biosynthetic process-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLAAT3 →	-0.298	-0.222	.006	<.001	3	4
SOFT_TISSUE	GZF1 →	+0.252	+0.210	.001	<.001	3	4
STOMACH	GET1 →	+0.120	+0.081	.007	.005	3	4
LIVER	LRP2 →	-0.206	-0.243	.001	<.001	3	3
UPPER_AERODIGESTIVE_TRACT	AKR1A1 →	-0.288	-0.200	.007	.003	3	3
UPPER_AERODIGESTIVE_TRACT	FASTK →	-0.282	-0.166	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLAAT3 by Negative regulation of nucleotide biosynthetic process activity — SOFT_TISSUE

Explore this box plot interactively →