Regulation of nucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Regulation of nucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDIPT, MESP1, and OTULINL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nucleotide biosynthetic process activity versus CDIPT in URINARY_TRACT (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CDIPT →	+0.990	+0.199	<.001	.002	3	5
LUNG_NSCLC_LUSC	MESP1 →	+1.150	+0.372	.008	.006	3	5
LUNG_SCLC	OTULINL →	+1.862	+0.253	.008	.001	3	4
LUNG_SCLC	HS3ST3A1 →	-0.796	-0.218	.001	<.001	3	4
BREAST	SMURF1 →	-0.703	-0.195	.003	.001	2	5
LARGE_INTESTINE	ATP5IF1 →	+1.017	+0.312	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030808 vs CDIPT — URINARY_TRACT

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