Ovulation

Across TCGA patient cohorts, RNA activity of the Ovulation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SCN1B, DHCR24-DT, and ECT2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ovulation activity versus SCN1B in BRCA (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SCN1B →	+0.493	+0.581	<.001	<.001	3	6
COAD	DHCR24-DT →	-0.215	-0.200	.002	<.001	3	4
BRCA	ECT2 →	-0.762	-0.647	<.001	<.001	3	4
CCRCC	LHFPL6 →	+0.879	+0.506	<.001	.004	3	4
BRCA	ESR1 →	+2.151	+0.577	<.001	<.001	3	4
BRCA	SPINK4 →	+1.242	+0.766	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030728 vs SCN1B — BRCA

Explore this scatter interactively →