Ovulation

Across TCGA cell cohorts, RNA activity of the Ovulation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SF3B1, ZDHHC12, and RNF43, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SF3B1 grouped by Ovulation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SF3B1 →	-0.453	-0.897	.003	<.001	3	4
PANCREAS	ZDHHC12 →	-0.936	-1.251	.001	.001	3	4
LUNG_SCLC	RNF43 →	-1.738	-0.856	.002	.009	3	3
LUNG_SCLC	EPB41 →	-2.099	-1.101	.002	.001	3	3
LUNG_SCLC	NUP160 →	-0.682	-1.143	.008	.007	3	3
LUNG_SCLC	ZNF302 →	-1.519	-1.072	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SF3B1 by Ovulation activity — LUNG_SCLC

Explore this box plot interactively →