Ovulation

Across TCGA cell cohorts, RNA activity of the Ovulation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRK, BCL2L1, and WDR20, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTPRK grouped by Ovulation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PTPRK →	+0.201	+1.477	.006	.006	3	5
LUNG_NSCLC_LUAD	BCL2L1 →	+0.701	+0.668	.001	.006	3	4
LUNG_SCLC	WDR20 →	-0.291	-1.669	.002	<.001	3	3
LUNG_SCLC	TSSC4 →	+0.169	+1.214	.003	.003	2	4
BONE	PRPS2 →	-0.190	-1.681	.006	<.001	3	3
BLOOD_Leukemia	DSG3 →	-0.278	-1.327	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTPRK by Ovulation activity — SOFT_TISSUE

Explore this box plot interactively →