Cytoskeleton-dependent intracellular transport

Across TCGA patient cohorts, RNA activity of the Cytoskeleton-dependent intracellular transport pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RPL5, IFT122, and CETN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoskeleton-dependent intracellular transport activity versus RPL5 in GBM (Pearson r = -0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RPL5 →	-0.251	-0.044	<.001	<.001	3	7
BRCA	IFT122 →	+0.276	+0.018	<.001	<.001	3	7
HNSC	CETN2 →	+0.280	+0.042	<.001	.005	3	7
HNSC	RPL24 →	-0.273	-0.057	<.001	<.001	3	6
HNSC	TP53BP1_T922 →	+0.557	+0.082	<.001	<.001	3	6
LSCC	MICALL1 →	-0.315	-0.025	.003	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030705 vs RPL5 — GBM

Explore this scatter interactively →