Cytoskeleton-dependent intracellular transport

Across TCGA cell cohorts, RNA activity of the Cytoskeleton-dependent intracellular transport pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DARS2, GOT2, and INHBA, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cytoskeleton-dependent intracellular transport activity versus DARS2 in OESOPHAGUS (Pearson r = -0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	DARS2 →	-0.642	-0.158	.002	.001	3	7
SOFT_TISSUE	GOT2 →	-1.258	-0.231	.002	.002	3	6
BONE	INHBA →	+3.087	+0.166	.002	.006	3	6
STOMACH	TBC1D30 →	-2.034	-0.105	.002	.005	3	5
LIVER	SORD →	-1.326	-0.194	.005	.007	2	6
BREAST	ITGB1 →	+1.436	+0.165	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030705 vs DARS2 — OESOPHAGUS

Explore this scatter interactively →