Regulation of vitamin metabolic process

Across TCGA patient cohorts, RNA activity of the Regulation of vitamin metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AMPD3, NADK, and PTPN2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin metabolic process activity versus AMPD3 in GBM (Pearson r = 0.40).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	AMPD3 →	+0.535	+0.057	<.001	<.001	3	7
COAD	NADK →	+0.413	+0.039	<.001	<.001	3	7
PDAC	PTPN2 →	+0.247	+0.048	.002	.003	3	7
COAD	CRLF3 →	+0.312	+0.032	<.001	<.001	3	7
GBM	EHBP1L1 →	+0.366	+0.053	<.001	.001	3	7
LSCC	FKBP15_S1012 →	+0.387	+0.054	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030656 vs AMPD3 — GBM

Explore this scatter interactively →