Regulation of vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NRXN2, CLSTN3, and PPIL3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NRXN2 grouped by Regulation of vitamin metabolic process-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	NRXN2 →	+2.649	+1.406	<.001	<.001	3	5
BONE	CLSTN3 →	+1.729	+1.441	<.001	<.001	3	4
BONE	PPIL3 →	+0.664	+1.459	.007	.003	3	4
BLOOD_Leukemia	ALAS2 →	+3.732	+1.204	.002	<.001	3	4
LUNG_NSCLC_LUSC	TIGD1 →	+0.936	+1.204	.001	<.001	3	4
BLOOD_Leukemia	TSTD2 →	+0.766	+0.865	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NRXN2 by Regulation of vitamin metabolic process activity — BONE

Explore this box plot interactively →