Regulation of vitamin metabolic process

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIRT6, ZNF251, and AKR1C1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin metabolic process activity versus SIRT6 in STOMACH (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SIRT6 →	+0.931	+1.378	.005	.003	2	5
LIVER	ZNF251 →	+0.662	+1.444	.004	.003	3	4
LUNG_NSCLC_LUAD	AKR1C1 →	+4.730	+0.976	<.001	.003	3	4
LUNG_NSCLC_LUAD	SLC48A1 →	+1.032	+0.871	.001	.007	3	4
LUNG_NSCLC_LUAD	FSBP →	+0.898	+1.151	.003	.002	3	4
STOMACH	MIEF2 →	-0.885	-1.613	.008	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030656 vs SIRT6 — STOMACH

Explore this scatter interactively →