Intracellular phosphate ion homeostasis

Across TCGA patient cohorts, RNA activity of the Intracellular phosphate ion homeostasis pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SLC34A2, SNX4, and XPR1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Intracellular phosphate ion homeostasis activity versus SLC34A2 in CCRCC (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SLC34A2 →	+1.798	+0.150	<.001	<.001	3	6
CCRCC	SNX4 →	+0.253	+0.125	<.001	<.001	3	5
OV	XPR1 →	+0.661	+0.081	<.001	.003	3	5
GBM	TMEM192 →	+0.344	+0.060	.001	.004	3	5
UCEC	ST6GAL1 →	+0.378	+0.076	.009	.002	3	5
PDAC	DNAJC9 →	-0.337	-0.104	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030643 vs SLC34A2 — CCRCC

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