Polyketide metabolic process

Across TCGA patient cohorts, RNA activity of the Polyketide metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKR1C1, GFPT2_T227, and AKR1B10, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyketide metabolic process activity versus AKR1C1 in LSCC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C1 →	+2.077	+0.211	<.001	<.001	3	6
CCRCC	GFPT2_T227 →	-1.382	-0.095	<.001	.001	3	6
LUAD	AKR1B10 →	+2.736	+0.142	<.001	<.001	3	6
UCEC	AKR1C2 →	+2.473	+0.140	<.001	<.001	3	6
LSCC	AKR1C3 →	+1.882	+0.224	<.001	<.001	3	6
LUAD	TXNRD1 →	+0.855	+0.169	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030638 vs AKR1C1 — LSCC

Explore this scatter interactively →