Polyketide metabolic process

Across TCGA cell cohorts, RNA activity of the Polyketide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKR1A1, PGD, and AKR1C1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Polyketide metabolic process activity versus AKR1A1 in STOMACH (Pearson r = 0.55).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	AKR1A1 →	+1.031	+1.178	.007	.007	2	7
LUNG_NSCLC_LUAD	PGD →	+1.860	+0.959	<.001	.004	3	5
LUNG_NSCLC_LUSC	AKR1C1 →	+6.295	+1.523	<.001	.006	3	5
OVARY	RSAD1 →	+1.007	+1.074	<.001	.008	3	5
BLOOD_Leukemia	BTBD2 →	+0.839	+0.201	<.001	.003	3	5
BLOOD_Lymphoma	JCHAIN →	+6.647	+0.295	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030638 vs AKR1A1 — STOMACH

Explore this scatter interactively →