Neutrophil chemotaxis

Across TCGA patient cohorts, RNA activity of the Neutrophil chemotaxis pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, RCSD1_S351, and RIN3, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil chemotaxis activity versus RCSD1 in OV (Pearson r = 0.33).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1 →	+0.743	+0.063	<.001	<.001	3	10
OV	RCSD1_S351 →	+0.848	+0.063	<.001	<.001	3	10
COAD	RIN3 →	+0.518	+0.035	<.001	.001	3	10
LSCC	SAMSN1_S23 →	+0.858	+0.087	<.001	<.001	3	10
OV	SASH3 →	+0.597	+0.071	<.001	<.001	3	10
GBM	SKAP2 →	+0.746	+0.092	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030593 vs RCSD1 — OV

Explore this scatter interactively →