Neutrophil chemotaxis

Across TCGA patient cohorts, RNA activity of the Neutrophil chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R5, FGR, and PARP15, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil chemotaxis activity versus PIK3R5 in LSCC (Pearson r = 0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	PIK3R5 →	+0.692	+0.224	<.001	<.001	3	9
BRCA	FGR →	+0.972	+0.265	<.001	<.001	3	9
LSCC	PARP15 →	+0.874	+0.207	<.001	<.001	3	8
GBM	CD163 →	+1.274	+0.147	<.001	<.001	3	8
GBM	LILRB1 →	+0.915	+0.208	<.001	<.001	3	8
LSCC	CD4 →	+0.650	+0.196	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030593 vs PIK3R5 — LSCC

Explore this scatter interactively →