Neutrophil chemotaxis

Across TCGA cell cohorts, RNA activity of the Neutrophil chemotaxis pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAPGEF1, TRAM1, and ARHGDIG, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAPGEF1 grouped by Neutrophil chemotaxis-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	RAPGEF1 →	-0.523	-0.228	.006	.004	3	4
SKIN	TRAM1 →	-0.155	-0.754	<.001	.007	2	5
CNS	ARHGDIG →	-0.324	-0.838	<.001	.001	3	4
LUNG_NSCLC_LUSC	LPGAT1 →	-0.175	-0.223	.002	.001	3	3
CNS	PTGIR →	-0.126	-0.578	.001	.003	3	3
LUNG_NSCLC_LUSC	RRM1 →	-0.445	-0.203	.002	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAPGEF1 by Neutrophil chemotaxis activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →