Neutrophil chemotaxis

Across TCGA cell cohorts, RNA activity of the Neutrophil chemotaxis pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL1, SC5D, and COA1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL1 grouped by Neutrophil chemotaxis-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ST3GAL1 →	-3.075	-1.856	.002	<.001	3	3
BLOOD_Lymphoma	SC5D →	-1.256	-1.711	.008	<.001	3	3
OVARY	COA1 →	+0.645	+0.965	<.001	.004	3	3
OVARY	PLEKHM2 →	-0.812	-1.031	.003	.004	3	3
PANCREAS	SGPL1 →	-0.656	-0.889	.005	.005	3	3
BLOOD_Leukemia	ANGPTL3 →	+0.062	+1.291	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL1 by Neutrophil chemotaxis activity — LIVER

Explore this box plot interactively →