PML body organization

Across TCGA patient cohorts, RNA activity of the PML body organization pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ETS1, CMPK2, and GNB4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, PML body organization activity versus ETS1 in PDAC (Pearson r = 0.47).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	ETS1 →	+0.570	+0.055	.002	<.001	3	7
GBM	CMPK2 →	+0.476	+0.049	<.001	.005	3	6
LSCC	GNB4 →	+0.349	+0.072	<.001	<.001	3	6
HNSC	ICAM2 →	+0.380	+0.096	<.001	.003	3	6
HNSC	JPT2 →	-0.352	-0.113	<.001	<.001	3	6
BRCA	FGD5 →	+0.353	+0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030578 vs ETS1 — PDAC

Explore this scatter interactively →