PML body organization

Across TCGA patient cohorts, RNA activity of the PML body organization pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HABP4, VCAM1, and DEGS2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, PML body organization activity versus HABP4 in LSCC (Pearson r = 0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	HABP4 →	+0.439	+0.195	<.001	<.001	3	4
GBM	VCAM1 →	+1.342	+0.156	<.001	.007	3	4
CCRCC	DEGS2 →	-0.340	-0.175	.005	.005	3	4
HNSC	PML →	+0.531	+0.234	.006	.002	3	4
PDAC	GJA1 →	+0.690	+0.157	.001	.007	3	4
HNSC	SERPING1 →	+0.698	+0.216	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030578 vs HABP4 — LSCC

Explore this scatter interactively →