PML body organization

Across TCGA cell cohorts, RNA activity of the PML body organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RHEBL1, ARHGAP24, and BOD1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RHEBL1 grouped by PML body organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RHEBL1 →	-1.679	-1.068	<.001	.004	3	4
LIVER	ARHGAP24 →	-1.725	-1.359	.001	.004	3	4
LIVER	BOD1 →	-0.503	-1.676	.001	.002	3	4
CNS	BCAR3 →	-1.163	-1.361	.008	<.001	3	4
OESOPHAGUS	PEX5 →	+0.711	+1.255	<.001	<.001	3	4
LIVER	CPLX1 →	+1.579	+1.324	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RHEBL1 by PML body organization activity — BLOOD_Leukemia

Explore this box plot interactively →