Nuclear body organization

Across TCGA patient cohorts, RNA activity of the Nuclear body organization pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FKBP5, ARFGEF1, and CDH1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear body organization activity versus FKBP5 in LUAD (Pearson r = 0.24).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FKBP5 →	+0.334	+0.043	<.001	<.001	3	5
BRCA	ARFGEF1 →	-0.393	-0.028	<.001	.002	3	5
UCEC	CDH1 →	-0.265	-0.049	.004	<.001	3	5
UCEC	CTNND1_T906 →	-0.399	-0.049	<.001	.003	3	5
BRCA	GNB4 →	+0.288	+0.036	<.001	<.001	3	5
OV	GPRC5A →	-0.855	-0.045	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030575 vs FKBP5 — LUAD

Explore this scatter interactively →