Nuclear body organization

Across TCGA cell cohorts, RNA activity of the Nuclear body organization pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CZIB, PAX9, and UGGT2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CZIB grouped by Nuclear body organization-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CZIB →	-0.569	-1.262	<.001	<.001	3	4
BREAST	PAX9 →	+1.061	+0.442	<.001	.005	2	5
KIDNEY	UGGT2 →	-0.720	-1.270	.007	.005	3	4
BREAST	IQCE →	+0.833	+0.490	<.001	.001	3	3
BREAST	MT2A →	-2.201	-0.754	<.001	.001	3	3
BREAST	CGN →	+1.229	+0.441	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CZIB by Nuclear body organization activity — BLOOD_Leukemia

Explore this box plot interactively →