Nuclear body organization

Across TCGA cell cohorts, RNA activity of the Nuclear body organization pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OGFRL1, WDR3, and CSDE1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nuclear body organization activity versus OGFRL1 in PANCREAS (Pearson r = -0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	OGFRL1 →	-1.038	-0.284	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	WDR3 →	+0.974	+0.371	.002	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CSDE1 →	+0.865	+0.294	.007	.001	2	5
BLOOD_Lymphoma	SLX1A →	+0.776	+0.257	.006	<.001	3	3
BLOOD_Lymphoma	BTG1 →	-1.068	-0.159	.001	.003	3	3
BLOOD_Lymphoma	NDUFV1 →	+0.456	+0.210	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030575 vs OGFRL1 — PANCREAS

Explore this scatter interactively →