Collagen catabolic process

Across TCGA patient cohorts, RNA activity of the Collagen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPEP2, CD14, and SIRPB2, each associated with the pathway in up to 29 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen catabolic process activity versus DPEP2 in SCLC (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SCLC	DPEP2 →	+1.289	+0.274	<.001	<.001	3	29
ACC	CD14 →	+2.067	+0.065	<.001	<.001	3	29
DLBC	SIRPB2 →	+1.054	+0.050	<.001	.001	3	29
ACC	TYROBP →	+1.712	+0.065	<.001	<.001	3	28
SCLC	MYO1F →	+1.814	+0.287	<.001	<.001	3	28
SCLC	GPR132 →	+1.300	+0.256	<.001	<.001	3	28

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030574 vs DPEP2 — SCLC

Explore this scatter interactively →