Collagen catabolic process

Across TCGA patient cohorts, RNA activity of the Collagen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LOXL2, CEACAM3, and COL1A1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen catabolic process activity versus LOXL2 in OV (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	LOXL2 →	+1.338	+0.295	<.001	<.001	3	9
COAD	CEACAM3 →	+0.569	+0.153	<.001	<.001	3	8
OV	COL1A1 →	+2.860	+0.322	<.001	<.001	3	8
COAD	COL12A1 →	+1.187	+0.231	<.001	<.001	3	8
COAD	CCN1 →	+1.376	+0.278	<.001	<.001	3	8
OV	PDPN →	+1.455	+0.350	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030574 vs LOXL2 — OV

Explore this scatter interactively →