Collagen catabolic process

Across TCGA cell cohorts, RNA activity of the Collagen catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C2CD3, GMCL1, and SC5D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen catabolic process activity versus C2CD3 in LARGE_INTESTINE (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C2CD3 →	-0.875	-0.327	<.001	<.001	3	5
BLOOD_Lymphoma	GMCL1 →	-0.703	-0.201	.007	.006	3	5
SOFT_TISSUE	SC5D →	-1.685	-0.443	<.001	.004	3	4
BLOOD_Myeloma	SIPA1L3 →	-1.266	-0.301	.002	.008	3	4
BLOOD_Lymphoma	TNNI1 →	-3.399	-0.341	.009	<.001	3	4
BLOOD_Lymphoma	TAGAP →	-2.590	-0.310	.003	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030574 vs C2CD3 — LARGE_INTESTINE

Explore this scatter interactively →