Male genitalia development

Across TCGA patient cohorts, RNA activity of the Male genitalia development pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GIMAP8, TBX3_S456, and ROBO4_S508, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Male genitalia development activity versus GIMAP8 in HNSC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GIMAP8 →	-0.305	-0.048	.001	<.001	3	6
BRCA	TBX3_S456 →	+1.127	+0.059	<.001	<.001	3	5
HNSC	ROBO4_S508 →	-0.379	-0.092	.001	.006	3	4
HNSC	SAMHD1 →	-0.380	-0.060	.002	<.001	3	4
HNSC	TBX3_S707 →	+0.268	+0.039	.001	.007	3	4
HNSC	TLE3_S203 →	+0.466	+0.082	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030539 vs GIMAP8 — HNSC

Explore this scatter interactively →