Male genitalia development

Across TCGA cell cohorts, RNA activity of the Male genitalia development pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP131, KIFAP3, and HOXA3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP131 grouped by Male genitalia development-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CEP131 →	-0.609	-0.960	.002	.003	3	4
SKIN	KIFAP3 →	+0.887	+1.237	<.001	<.001	3	4
LUNG_SCLC	HOXA3 →	-1.619	-1.000	.002	.002	3	4
PANCREAS	TXK →	+1.236	+0.993	.004	.004	3	3
BREAST	KCNMB4 →	-0.689	-0.713	.003	.002	2	4
BREAST	ZNF528 →	-1.826	-0.751	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP131 by Male genitalia development activity — LUNG_SCLC

Explore this box plot interactively →