Adult behavior

Across TCGA patient cohorts, RNA activity of the Adult behavior pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RNASEH2B, SEPTIN1, and PARP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult behavior activity versus RNASEH2B in UCEC (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNASEH2B →	-0.491	-0.041	<.001	<.001	3	6
BRCA	SEPTIN1 →	-0.465	-0.020	.003	<.001	3	6
HNSC	PARP1 →	-0.362	-0.025	<.001	.001	3	6
LUAD	ARHGAP32 →	+0.315	+0.033	<.001	.001	3	6
CCRCC	LRBA_S2496 →	+0.406	+0.026	.002	.003	3	6
COAD	IWS1_S302 →	-0.382	-0.010	.008	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030534 vs RNASEH2B — UCEC

Explore this scatter interactively →