Adult behavior

Across TCGA patient cohorts, RNA activity of the Adult behavior pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDAH1, FABP4, and ZNF728, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult behavior activity versus DDAH1 in HNSC (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	DDAH1 →	+0.682	+0.488	.001	<.001	3	5
COAD	FABP4 →	+1.221	+0.146	.005	<.001	3	5
LSCC	ZNF728 →	+0.362	+0.937	<.001	<.001	3	5
COAD	C7 →	+1.140	+0.204	.005	<.001	3	4
HNSC	EFHD1 →	+0.977	+0.401	<.001	<.001	3	4
BRCA	AOX1 →	+0.892	+0.341	.001	.006	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030534 vs DDAH1 — HNSC

Explore this scatter interactively →