Adult behavior

Across TCGA cell cohorts, RNA activity of the Adult behavior pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AFAP1, TXNDC12, and PICK1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AFAP1 grouped by Adult behavior-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	AFAP1 →	+2.955	+0.332	<.001	<.001	3	3
STOMACH	TXNDC12 →	-0.752	-0.177	.001	.001	3	3
SKIN	PICK1 →	-0.862	-0.165	.001	.001	3	3
SKIN	CD101 →	+0.567	+0.150	.004	.008	3	3
SOFT_TISSUE	COL6A2 →	+4.234	+0.339	.006	.003	3	3
URINARY_TRACT	MUC12 →	-1.341	-0.341	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AFAP1 by Adult behavior activity — SOFT_TISSUE

Explore this box plot interactively →