Adult behavior

Across TCGA cell cohorts, RNA activity of the Adult behavior pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KRT16, DCAF4L1, and MYL6B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Adult behavior activity versus KRT16 in PANCREAS (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	KRT16 →	-1.411	-0.056	<.001	<.001	3	7
PANCREAS	DCAF4L1 →	-0.277	-0.052	.004	.003	3	6
OESOPHAGUS	MYL6B →	+1.006	+0.076	<.001	.005	3	6
PANCREAS	TRAPPC1 →	+0.813	+0.055	<.001	.006	3	6
URINARY_TRACT	CFAP61 →	+0.217	+0.075	.005	.001	3	5
LIVER	LSG1 →	-1.198	-0.096	<.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030534 vs KRT16 — PANCREAS

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