Androgen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the DLBC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNRC6B, NFAT5, and ELF2, each associated with the pathway in up to 34 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen receptor signaling pathway activity versus TNRC6B in DLBC (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	TNRC6B →	+1.159	+0.059	<.001	<.001	3	34
THYM	NFAT5 →	+2.011	+0.082	<.001	<.001	3	34
DLBC	ELF2 →	+1.131	+0.061	<.001	<.001	3	34
DLBC	USP34 →	+2.086	+0.059	<.001	<.001	3	34
DLBC	MTR →	+1.378	+0.059	<.001	<.001	3	34
CHOL	BAZ2B →	+1.088	+0.069	<.001	<.001	3	34

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030521 vs TNRC6B — DLBC

Explore this scatter interactively →