Androgen receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RMND1, DDX49, and ATP11C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen receptor signaling pathway activity versus RMND1 in HNSC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RMND1 →	+0.437	+0.377	.001	.007	3	4
CCRCC	DDX49 →	+0.169	+0.214	.006	.001	3	4
LSCC	ATP11C →	+0.326	+0.109	.003	.009	3	4
LSCC	AKAP8 →	+0.366	+0.157	.001	.001	3	4
LSCC	ILF3 →	+0.505	+0.174	.001	<.001	3	4
LSCC	C12orf65 →	+0.422	+0.248	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030521 vs RMND1 — HNSC

Explore this scatter interactively →