Androgen receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Androgen receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WNK2, CLIC1, and GPC2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Androgen receptor signaling pathway activity versus WNK2 in LIVER (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	WNK2 →	+2.805	+0.183	.007	.004	3	6
LIVER	CLIC1 →	-1.663	-0.231	<.001	.002	3	6
CNS	GPC2 →	+1.532	+0.150	<.001	<.001	3	6
LUNG_NSCLC_LUSC	PTCD3 →	+1.165	+0.333	.004	.004	3	5
SOFT_TISSUE	DNAJC27 →	+0.742	+0.382	.007	.002	3	5
STOMACH	PRSS27 →	+0.797	+0.212	.004	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030521 vs WNK2 — LIVER

Explore this scatter interactively →