Negative regulation of axon extension

Across TCGA patient cohorts, RNA activity of the Negative regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, RNA5SP118, and CBX6, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of axon extension activity versus MAP2 in LSCC (Pearson r = 0.77).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+2.024	+0.891	<.001	<.001	3	7
LSCC	RNA5SP118 →	+1.610	+0.865	<.001	<.001	3	7
LSCC	CBX6 →	+0.667	+0.727	<.001	.001	3	5
LSCC	RHEB →	+0.373	+0.647	.002	<.001	3	4
LSCC	KIAA0319 →	+1.003	+0.594	<.001	<.001	3	4
LSCC	FAXC →	+0.762	+0.669	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030517 vs MAP2 — LSCC

Explore this scatter interactively →