Negative regulation of axon extension

Across TCGA cell cohorts, RNA activity of the Negative regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KLHL32, ITGA3, and CHRFAM7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KLHL32 grouped by Negative regulation of axon extension-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLHL32 →	+0.108	+1.211	.004	.003	3	4
OESOPHAGUS	ITGA3 →	-2.410	-1.345	.001	.004	3	4
URINARY_TRACT	CHRFAM7A →	+1.276	+1.606	.002	<.001	2	5
UPPER_AERODIGESTIVE_TRACT	PTK2B →	-1.388	-1.580	.002	<.001	3	4
STOMACH	P2RX6 →	-1.083	-0.948	.003	.004	3	4
CNS	KDELR3 →	-1.561	-0.992	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KLHL32 by Negative regulation of axon extension activity — OESOPHAGUS

Explore this box plot interactively →