Negative regulation of axon extension

Across TCGA cell cohorts, RNA activity of the Negative regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM3C, SDC4, and ITGB6, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of axon extension activity versus FAM3C in LUNG_NSCLC_LUAD (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FAM3C →	+1.677	+0.394	<.001	<.001	3	9
LARGE_INTESTINE	SDC4 →	+1.808	+0.373	<.001	<.001	3	8
PANCREAS	ITGB6 →	+2.072	+0.262	.008	.009	2	8
BLOOD_Lymphoma	TAF5 →	-0.568	-1.176	<.001	.001	3	7
LUNG_NSCLC_LUAD	SCEL →	+3.756	+0.325	<.001	<.001	3	6
LARGE_INTESTINE	ATP5F1A →	-1.107	-0.300	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030517 vs FAM3C — LUNG_NSCLC_LUAD

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