Regulation of axon extension

Across TCGA patient cohorts, RNA activity of the Regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the CHOL cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP300, DLG5, and SMG1, each associated with the pathway in up to 32 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axon extension activity versus EP300 in CHOL (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CHOL	EP300 →	+1.416	+0.045	<.001	<.001	3	32
THYM	DLG5 →	+2.128	+0.052	<.001	<.001	3	31
CHOL	SMG1 →	+1.171	+0.038	<.001	<.001	3	31
THYM	PEAK1 →	+1.128	+0.051	<.001	<.001	3	31
DLBC	MAN2A2 →	+1.150	+0.035	.001	<.001	3	31
THYM	CICP14 →	+1.488	+0.042	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030516 vs EP300 — CHOL

Explore this scatter interactively →