Regulation of axon extension

Across TCGA patient cohorts, RNA activity of the Regulation of axon extension pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TCOF1_S233, LAMB1, and MAP2_T290, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axon extension activity versus TCOF1_S233 in BRCA (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TCOF1_S233 →	-0.586	-0.017	.005	.004	3	6
LUAD	LAMB1 →	+0.356	+0.036	<.001	<.001	3	6
UCEC	MAP2_T290 →	+0.767	+0.052	.001	.003	3	6
OV	HNRNPC →	-0.594	-0.041	.002	.003	3	6
LSCC	MAP1B →	+0.832	+0.038	<.001	.003	3	6
LUAD	COL1A2 →	+0.445	+0.032	.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030516 vs TCOF1_S233 — BRCA

Explore this scatter interactively →