Regulation of axon extension

Across TCGA cell cohorts, RNA activity of the Regulation of axon extension pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIAA0100, CALU, and SCLY, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of axon extension activity versus KIAA0100 in BREAST (Pearson r = -0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	KIAA0100 →	-0.829	-0.167	.006	.008	3	5
LIVER	CALU →	+1.435	+0.323	.009	.001	3	5
OESOPHAGUS	SCLY →	-0.938	-0.260	.005	.008	3	5
LUNG_NSCLC_LUAD	DNAH5 →	+0.894	+0.239	<.001	<.001	3	5
CNS	HSPA9 →	-0.466	-0.197	.002	.003	3	5
LUNG_NSCLC_LUSC	LY6K →	+4.358	+0.237	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030516 vs KIAA0100 — BREAST

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