Negative regulation of BMP signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of BMP signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIML2, GPR26, and TAF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIML2 grouped by Negative regulation of BMP signaling pathway-low versus -high activity in BONE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	TRIML2 →	+0.141	+0.108	.003	.007	3	4
SOFT_TISSUE	GPR26 →	-0.113	-0.076	.003	.001	3	4
SOFT_TISSUE	TAF3 →	-0.260	-0.091	.004	.002	3	4
STOMACH	ZNF16 →	+0.206	+0.103	.004	.007	3	4
BONE	MAX →	-0.548	-0.112	.002	.001	3	4
CNS	TTC16 →	+0.178	+0.094	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIML2 by Negative regulation of BMP signaling pathway activity — BONE

Explore this box plot interactively →