Negative regulation of BMP signaling pathway

Across TCGA cell cohorts, RNA activity of the Negative regulation of BMP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RALGAPA2, PLEKHH1, and VWA8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of BMP signaling pathway activity versus RALGAPA2 in BLOOD_Leukemia (Pearson r = -0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	RALGAPA2 →	-0.922	-0.663	.003	.007	3	6
BLOOD_Lymphoma	PLEKHH1 →	-0.895	-0.845	.005	.005	3	5
OESOPHAGUS	VWA8 →	-1.397	-1.191	<.001	.001	3	5
SOFT_TISSUE	CAV2 →	+3.564	+1.213	.001	<.001	3	5
KIDNEY	SLC45A4 →	-1.535	-1.247	.001	.004	3	5
BLOOD_Lymphoma	SPPL2A →	-1.046	-0.834	.006	.005	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030514 vs RALGAPA2 — BLOOD_Leukemia

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