Positive regulation of BMP signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of BMP signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DUSP28, CD22, and E2F1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of BMP signaling pathway activity versus DUSP28 in LIVER (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DUSP28 →	+0.650	+1.211	.004	.001	2	5
BLOOD_Lymphoma	CD22 →	+4.269	+0.889	.003	.001	3	4
OVARY	E2F1 →	+1.213	+1.014	.007	<.001	3	3
BLOOD_Lymphoma	EXTL2 →	-0.999	-0.794	.002	.003	3	3
LARGE_INTESTINE	CSPG5 →	-0.723	-0.780	<.001	<.001	3	3
LARGE_INTESTINE	XPO5 →	-0.506	-0.724	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0030513 vs DUSP28 — LIVER

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